反应详情

温度

40 °C

To the obtained bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine, TFA (3 ml) and concentrated sulfuric acid (a few drops) were added, followed by stirring at 40° C. for 6 hours. This was concentrated under reduced pressure, and water was added, followed by neutralization with 1N aqueous sodium hydroxide solution. The resulting solid was purified by silica gel column chromatography (dichloromethane/2N ammonia methanol=40/1 to 10/1), to obtain the desired compound as a colorless solid (32.3 mg, yield 26%).

1. concentrationThis was concentrated under reduced pressure, and water
2. additionwas added
3. customThe resulting solid was purified by silica gel column chromatography (dichloromethane/2N ammonia methanol=40/1 to 10/1)