Boronic Acid → HCID 59244893, compound

HRID 912127Notes

Reaction equation

HRID 912127 reaction equation
Cl[C:2]1[C:3]2[CH2:16][CH2:15][N:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[C:4]=2[N:5]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:7]=1.[OH:23][CH2:24][C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][CH:30]=1.B(O)O>>[N:8]1([C:6]2[N:7]=[C:2]([C:29]3[CH:30]=[C:25]([CH2:24][OH:23])[CH:26]=[CH:27][CH:28]=3)[C:3]3[CH2:16][CH2:15][N:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[C:4]=3[N:5]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 2734662[3-(Hydroxymethyl)phenyl]boronic acidHCID 592450134-Chloro-2-morpholin-4-yl-7-pyridin-3-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 59244893HCID 59244893, compound

Procedure

In the same manner as Example 1-B-10, using 4-chloro-2-morpholin-4-yl-7-pyridin-3-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine, and 3-(hydroxymethyl)phenylboronic acid as a boronic acid, the desired compound was obtained.

Sources & evidence

ORD record
ord-2ab181cc33c54d23ab0816062183e3a7
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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