HCID 59244872, compound → HCID 24888234, compound

HRID 912140Notes

Reaction equation

HRID 912140 reaction equation
C([O:5][C:6]1[CH:7]=[C:8]([C:12]2[C:13]3[CH2:26][CH2:25][N:24]([C:27](=[O:29])[CH3:28])[C:14]=3[N:15]=[C:16]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[N:17]=2)[CH:9]=[CH:10][CH:11]=1)(C)(C)C>FC(F)(F)C(O)=O>[OH:5][C:6]1[CH:7]=[C:8]([C:12]2[C:13]3[CH2:26][CH2:25][N:24]([C:27](=[O:29])[CH3:28])[C:14]=3[N:15]=[C:16]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[N:17]=2)[CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 1

HCID 59244872HCID 59244872, compound

Product 1

HCID 24888234HCID 24888234, compoundYield 64.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

1-[4-(3-t-Butoxyphenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-ethanone (20 mg) prepared according to Step E in Example 1-J-01 described later was dissolved in trifluoroacetic acid (500 μl), followed by stirring at room temperature for 30 minutes. The reaction mixture was concentrated under reduced pressure, and to the resulting residue, water (5 ml) and methanol (1 ml) were added, followed by neutralization with aqueous saturated sodium bicarbonate solution. The deposited precipitate was filtered off, followed by drying under reduced pressure, to obtain a colorless powder (11 mg, 64%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionto the resulting residue, water (5 ml) and methanol (1 ml) were added
  3. filtrationThe deposited precipitate was filtered off
  4. customby drying under reduced pressure

Sources & evidence

ORD record
ord-ecf3954c6fee4796aadb58ad782039a9
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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