反应详情

To a THF solution (3 ml) of 3-[(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carbonyl)-amino]-propionic acid ethyl ester (84 mg) obtained in Step A in Example 1-D-30, 5M-NaOH aqueous solution (1.5 ml) was added, followed by refluxing for 1 hour. The resulting solid was filtered, to obtain a crude product of the desired compound (78.2 mg, 97%)

1. temperatureby refluxing for 1 hour
2. filtrationThe resulting solid was filtered