HCID 723128, compound → HCID 16795691, compound

HRID 912224Notes

Reaction equation

HRID 912224 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-])=O)[CH:12]=2)=[O:10])[CH2:5][CH2:4]1)[CH3:2]>[Pd].CO>[NH2:17][C:13]1[CH:12]=[C:11]([C:9]([N:6]2[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5]2)=[O:10])[CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 1

HCID 723128HCID 723128, compound

Product 1

HCID 16795691HCID 16795691, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To methanol solution (5 ml) of (4-ethyl-piperazin-1-yl)-(3-nitro-phenyl)-methanone (365.3 mg) obtained in Step A, palladium black was added, followed by stirring at room temperature for 14 hours under a hydrogen gas atmosphere. This was filtered through Celite, and subsequently the solvent was distilled off under reduced pressure, to obtain the desired compound as a crude product (241.8 mg, 51%).

Workup

  1. filtrationThis was filtered through Celite
  2. distillationsubsequently the solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-60522f35b9f34244bfb4ca6e63e29c0b
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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