Benzene, 1-bromo-3-nitro- → HCID 21889081, compound

HRID 912228Notes

Reaction equation

HRID 912228 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[CH:3]=1.[N:11]1([CH2:17][CH2:18][NH2:19])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>>[N:11]1([CH2:17][CH2:18][NH:19][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[CH:3]=2)[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 11457Benzene, 1-bromo-3-nitro-HCID 4082852-Morpholinoethylamine

Product 1

HCID 21889081HCID 21889081, compound

Procedure

Using 1-bromo-3-nitro-benzene (303 mg) and 2-morpholin-4-yl-ethylamine (315 μl) instead of morpholine, in the same manner as Step A in Example 1-D-105, the desired compound was obtained (374.6 mg, 74%).

Sources & evidence

ORD record
ord-11a953aa586e44a7ba6e85f4589095aa
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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