1-Iodo-4-nitrobenzene → HCID 21975327, compound

HRID 912310Notes

Reaction equation

HRID 912310 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[N:11]1([CH2:17][CH2:18][CH2:19][NH2:20])[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>>[N:11]1([CH2:17][CH2:18][CH2:19][NH:20][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 124951-Iodo-4-nitrobenzeneHCID 61055N-(3-Aminopropyl)morpholine

Product 1

HCID 21975327HCID 21975327, compound

Procedure

Using 1-iodo-4-nitro-benzene (500 mg) instead of 1-bromo-3-nitro-benzene, and 3-morpholin-4-yl-propylamine (353 mg) instead of morpholine, in the same manner as Step A in Example 1-D-105, the desired compound was obtained (219 mg, 41%).

Sources & evidence

ORD record
ord-4b400211593047fa91bd529f1f6366a6
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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