反应详情

温度

80 °C

To a DMSO solution (8 ml) of 4-fluoro-2-methyl-1-nitro-benzene (500 mg), potassium carbonate (668 mg) and morpholine (0.42 ml) were added, followed by stirring at 80° C. for 18 hours. This was cooled to room temperature, and water (30 ml) was added, followed by extraction with ethyl acetate (50 ml×2). The organic layer was washed with saturated aqueous sodium chloride solution, followed by drying over magnesium sulfate. After the magnesium sulfate was filtered off, the solvent was distilled off under reduced pressure, to obtain the desired compound as a yellow solid (680 mg, 95%).

1. temperatureThis was cooled to room temperature
2. extractionfollowed by extraction with ethyl acetate (50 ml×2)
3. washThe organic layer was washed with saturated aqueous sodium chloride solution
4. dry with materialby drying over magnesium sulfate
5. filtrationAfter the magnesium sulfate was filtered off
6. distillationthe solvent was distilled off under reduced pressure