Methanol → HCID 14078298, compound

0.74 g (content 80%, 15.6 mmol) of lithium aluminum hydride was suspended in 7.0 g of THF, and the resultant suspension was cooled to 0° C. Next, 2.37 g(content 84.4%, 9.2 mmol) of 6,6-dimethoxy-2-methylheptanoic acid methyl ester was dissolved in 3.0 g of THF to give a solution which was then dropped into the above-described suspension at 0° C. over a period of 1.5 hours. Next, the reaction mixture as stirred at the same temperature for 3 hours, then, 1.47 g (45.9 mmol) of methanol was dropped to quench unreacted lithium aluminum hydride. Then, 2.74 g of a 2% sodium hydroxide aqueous solution was dropped at room temperature into the reaction mixture, then, the generated aluminum hydroxide was removed by filtration using Radiolite (filtration aid, trade name: manufactured by Showa Chemical Industry Co., Ltd.), subsequently, an acid treatment was performed, to obtain a uniform solution containing 1.07 g (yield 80.9%) of 7-hydroxy-6-methylheptan-2-one.

1. customto give a solution which
2. additionwas then dropped into the above-described suspension at 0° C. over a period of 1.5 hours
3. customto quench unreacted lithium aluminum hydride
4. additionThen, 2.74 g of a 2% sodium hydroxide aqueous solution was dropped at room temperature into the reaction mixture
5. customthe generated aluminum hydroxide was removed by filtration
6. filtrationRadiolite (filtration aid, trade name: manufactured by Showa Chemical Industry Co., Ltd.)
7. customto obtain a uniform solution

ORD record

ord-e8a776b894f549cda9f84660842d3ebb

Source dataset

uspto-grants-2011_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08026081B2