huagongshe.com
HRID912436

反应详情

EQUATION

反应方程式

HRID 912436 的结构方程式

REACTANTS

反应物

2
结构：CI
HCID6328

Methyl iodide

CH3I

结构：CC(C)(C)OC(=O)N[C@H]1CCNC1=O
HCID10750535

tert-Butyl [(3S)-2-oxopyrrolidin-3-yl]carbamate

C9H16N2O3

PRODUCTS

生成物

1
结构：CN1CC[C@H](NC(=O)OC(C)(C)C)C1=O
HCID57736562

1,1-Dimethylethyl N-[(3S)-1-methyl-2-oxo-3-pyrrolidinyl]carbamate

C10H18N2O3

PROCEDURE

实验过程

(S)-tert-butyl 1-methyl-2-oxopyrrolidin-3-ylcarbamate was prepared from compound (S)-tert-butyl 2-oxopyrrolidin-3-ylcarbamate (Example 6) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 25% acetone/hexanes to provide compound (2a) in 45% yield.

WORKUP

后处理

  1. customThe crude product was purified by column chromatography
  2. washeluting with 25% acetone/hexanes