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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 912436Generated: October 30, 2026

Methyl iodide → (S)-tert-Butyl (1-methyl-2-oxopyrrolidin-3-yl)carbamate

https://huagongshe.com/reaction/912436

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
Reactant(S)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamateHCID 10750535—
Product(S)-tert-Butyl (1-methyl-2-oxopyrrolidin-3-yl)carbamateHCID 57736562—

Reaction Steps

(S)-tert-butyl 1-methyl-2-oxopyrrolidin-3-ylcarbamate was prepared from compound (S)-tert-butyl 2-oxopyrrolidin-3-ylcarbamate (Example 6) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 25% acetone/hexanes to provide compound (2a) in 45% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08026233B2
Source datasetuspto-grants-2011_09
ORD IDord-90419a66d71941458cca50a5bbf94893
Source noteuspto-grants-2011_09