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HRID912437

反应详情

EQUATION

反应方程式

HRID 912437 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[Si](C)(C)OCCBr
HCID3608067

(2-Bromoethoxy)-tert-butyldimethylsilane

C8H19BrOSi

结构：CC(C)(C)OC(=O)N[C@H]1CCNC1=O
HCID10750535

tert-Butyl [(3S)-2-oxopyrrolidin-3-yl]carbamate

C9H16N2O3

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@H]1CCN(CCO[Si](C)(C)C(C)(C)C)C1=O
HCID57736552

未命名化合物

收率 37%

PROCEDURE

实验过程

(S)-tert-butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)-2-oxopyrrolidin-3-ylcarbamate was prepared from compound (s)-tert-butyl 2-oxopyrrolidin-3-ylcarbamate (Example 6) and (2-bromoethoxy)(tert-butyl)dimethylsilane according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 80% ethyl acetate/hexanes, to provide compound (2b) in 37% yield.

WORKUP

后处理

  1. customThe crude product was purified by column chromatography
  2. washeluting with 80% ethyl acetate/hexanes