HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Bromoethoxy)-tert-butyldimethylsilane → (S)-tert-butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)-2-oxopyrrolidin-3-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Bromoethoxy)-tert-butyldimethylsilane | HCID 3608067 | — |
| Reactant | (S)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamate | HCID 10750535 | — |
| Product | (S)-tert-butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)-2-oxopyrrolidin-3-ylcarbamate | HCID 57736552 | 37% |
Reaction Steps
(S)-tert-butyl 1-(2-(tert-butyldimethylsilyloxy)ethyl)-2-oxopyrrolidin-3-ylcarbamate was prepared from compound (s)-tert-butyl 2-oxopyrrolidin-3-ylcarbamate (Example 6) and (2-bromoethoxy)(tert-butyl)dimethylsilane according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 80% ethyl acetate/hexanes, to provide compound (2b) in 37% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026233B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-90d94143a2464ad7b9537d387ab82ff2 |
| Source note | uspto-grants-2011_09 |