Methyl iodide → HCID 57736564, compound

HRID 912438Notes

Reaction equation

HRID 912438 reaction equation
[O:1]=[C:2]1[C@@H:7]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:6][CH2:5][CH2:4][NH:3]1.[CH3:16]I>>[CH3:16][N:3]1[CH2:4][CH2:5][CH2:6][C@H:7]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:14])[CH3:13])[C:2]1=[O:1]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 1247873-tert-Butyloxycarbonylamino-2-piperidone

Product 1

HCID 57736564HCID 57736564, compound

Procedure

(S)-tert-butyl 1-methyl-2-oxopiperidin-3-ylcarbamate was prepared from (S)-tert-butyl 2-oxopiperidin-3-ylcarbamate (Example 7) and methyl iodide according to the general procedure of Example 9. The crude product was purified by column chromatography, eluting with 100% ethyl acetate, to provide compound (2c) in 31% yield.

Workup

  1. customThe crude product was purified by column chromatography
  2. washeluting with 100% ethyl acetate

Sources & evidence

ORD record
ord-93fcb1fc4a7146308502edf4c1dae0e2
Source dataset
uspto-grants-2011_09
Patent number
US08026233B2

Reaction notes

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