Hydrochloric Acid → (S)-3-Amino-1-methylpiperidin-2-one hydrochloride

HRID 912453Notes

Reaction equation

HRID 912453 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][C@H:4]([NH:8]C(=O)OC(C)(C)C)[C:3]1=[O:16].O1CCOCC1.[ClH:23]>>[ClH:23].[NH2:8][C@H:4]1[CH2:5][CH2:6][CH2:7][N:2]([CH3:1])[C:3]1=[O:16]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 57736564HCID 57736564, compound

Product 1

HCID 67416125(S)-3-Amino-1-methylpiperidin-2-one hydrochlorideYield 100%

Procedure

(S)-tert-Butyl 1-methyl-2-oxopiperidin-3-ylcarbamate (prepared according to Example 12; 78 mg, 0.34 mmol) was dissolved in 4M hydrogen chloride in dioxane (1.7 mL, 6.8 mmol), and the reaction was allowed to stir at ambient temperature for 16 hours. The reaction mixture was concentrated to yield (S)-3-amino-1-methylpiperidin-2-one hydrochloride (56 mg, 100%), which was taken on to the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-2664d30b45ba4f4389810dae02968e90
Source dataset
uspto-grants-2011_09
Patent number
US08026233B2

Reaction notes

Loading…