HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 912513Generated: October 30, 2026
Hydrochloric Acid → 4-(2-Hydroxyethoxy)-3-(trifluoromethyl)phenylboronic acid
https://huagongshe.com/reaction/912513
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)-3-(trifluoromethyl)phenylboronic acid | HCID 57657590 | — |
| Product | 4-(2-Hydroxyethoxy)-3-(trifluoromethyl)phenylboronic acid | HCID 57657540 | — |
Reaction Steps
4-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)-3-(trifluoromethyl)phenylboronic acid (8 g) was added to hydrochloric acid (1M in MeOH) and the mixture was heated at 60° C. for 60 minutes. Solvent and HCl was then removed under reduced pressure and residue (5.52 g) was used for next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08026236B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-85e19f2c4ac64c40a4820a4a0ef464a7 |
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| Source note | uspto-grants-2011_09 |
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