Hydrochloric Acid → 4-(2-Hydroxyethoxy)-3-(trifluoromethyl)phenylboronic acid

HRID 912513Notes

Reaction equation

HRID 912513 reaction equation
O1CCCCC1[O:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([B:17]([OH:19])[OH:18])=[CH:13][C:12]=1[C:20]([F:23])([F:22])[F:21].Cl>>[OH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([B:17]([OH:18])[OH:19])=[CH:13][C:12]=1[C:20]([F:23])([F:21])[F:22]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 576575904-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)-3-(trifluoromethyl)phenylboronic acid

Product 1

HCID 576575404-(2-Hydroxyethoxy)-3-(trifluoromethyl)phenylboronic acid

Conditions

Temperature
60 °C

Procedure

4-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)-3-(trifluoromethyl)phenylboronic acid (8 g) was added to hydrochloric acid (1M in MeOH) and the mixture was heated at 60° C. for 60 minutes. Solvent and HCl was then removed under reduced pressure and residue (5.52 g) was used for next step without further purification.

Workup

  1. customSolvent and HCl was then removed under reduced pressure and residue (5.52 g)
  2. customwas used for next step without further purification

Sources & evidence

ORD record
ord-85e19f2c4ac64c40a4820a4a0ef464a7
Source dataset
uspto-grants-2011_09
Patent number
US08026236B2

Reaction notes

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