Hydrochloric Acid → HCID 11462535, compound

HRID 912640Notes

Reaction equation

HRID 912640 reaction equation
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH:8]([NH:12][C:13]([NH:15][C:16]1[CH:24]=[CH:23][CH:22]=[C:21]3[C:17]=1[CH:18]=[N:19][N:20]3C(OC)=O)=[O:14])[CH2:7][CH2:6]2.Cl>>[NH:20]1[C:21]2[C:17](=[C:16]([NH:15][C:13]([NH:12][CH:8]3[C:9]4[C:5](=[CH:4][C:3]([C:2]([F:1])([F:29])[F:30])=[CH:11][CH:10]=4)[CH2:6][CH2:7]3)=[O:14])[CH:24]=[CH:23][CH:22]=2)[CH:18]=[N:19]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11316051Methyl 4-[[[[2,3-dihydro-5-(trifluoromethyl)-1H-inden-1-yl]amino]carbonyl]amino]-1H-indazole-1-carboxylate

Product 1

HCID 11462535HCID 11462535, compound

Procedure

The title compound was prepared using the procedure in Example 9, except using methyl 4-[({[5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]amino}carbonyl)amino]-1H-indazole-1-carboxylate instead of methyl 4-[({[5-tert-butyl-2,3-dihydro-1H-inden-1-yl]amino}carbonyl)amino]-1H-indazole-1-carboxylate. 1H NMR (DMSO-d6) δ 1.06 (t, 2.4H, EtOH), 1.82-1.94 (m, 1H), 2.52-2.60 (m, 1H), 2.85-2.97 (m, 1H), 2.98-3.10 (m, 1H), 3.44 (q, 1.6H, EtOH), 5.28 (m, 1H), 7.08 (m, 2H), 7.21 (m, 1H), 7.56 (m, 2H), 7.63 (s, 1H), 7.69 (d, 1H), 8.17 (s, 1H), 8.91 (s, 1H); MS (ESI+) 361 (M+H)+; Elemental: Calculated for C18H15N4OF3.HCl.0.8EtOH.0.1H2O: C, 54.06; H, 4.86; N, 12.87; Found: C, 54.02; H, 4.58; N, 12.62.

Sources & evidence

ORD record
ord-a10d248792b54acf8bb9968dc3735478
Source dataset
uspto-grants-2011_09
Patent number
US08026256B2

Reaction notes

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