Formic Acid → HCID 16755779, compound

HRID 912652Notes

Reaction equation

HRID 912652 reaction equation
[NH2:1][C:2]1[C:3](=[O:17])[NH:4][C:5](=[S:16])[N:6]([CH2:9][C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[C:7]=1[NH2:8].[CH:18](O)=O>[OH-].[Na+]>[N:13]1[CH:12]=[CH:11][C:10]([CH2:9][N:6]2[C:7]3[N:8]=[CH:18][NH:1][C:2]=3[C:3](=[O:17])[NH:4][C:5]2=[S:16])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 86631110HCID 86631110, compound

Product 1

HCID 16755779HCID 16755779, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The title compound was prepared in accordance with the general method described in Example 1(d), using 5,6-diamino-1-(pyridin-4-ylmethyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (0.25 g, 1.0 mmol, obtained from Example 3(b)), with the exception that 20 minutes of reaction time in formic acid was used, followed by a reaction time of 45 minutes in sodium hydroxide (10% aq.). The title compound was obtained (0.033, 13%) as a solid.

Workup

  1. customThe title compound was prepared in accordance with the general method

Sources & evidence

ORD record
ord-cdc6b3d14fc64d4596bc42021f72b636
Source dataset
uspto-grants-2011_09
Patent number
US08026244B2

Reaction notes

Loading…