HCID 86631115, compound → HCID 24855438, compound

HRID 912663Notes

Reaction equation

HRID 912663 reaction equation
C(N[C:10]([N:12]([CH2:21][C:22]1[NH:26][C:25]([CH2:27][CH2:28][CH2:29][CH3:30])=[N:24][C:23]=1[Cl:31])[C:13]1[N:14]=[CH:15][NH:16][C:17]=1[C:18]([NH2:20])=[O:19])=[S:11])(=O)C1C=CC=CC=1>N>[CH2:27]([C:25]1[NH:26][C:22]([CH2:21][N:12]2[C:13]3[N:14]=[CH:15][NH:16][C:17]=3[C:18](=[O:19])[NH:20][C:10]2=[S:11])=[C:23]([Cl:31])[N:24]=1)[CH2:28][CH2:29][CH3:30]

Participants

3

Reactant 1

HCID 86631115HCID 86631115, compound

Product 1

HCID 24855438HCID 24855438, compoundYield 14%

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Conditions

Temperature
80 °C

Procedure

4-{[(Benzoylamino)carbonothioyl][(2-butyl-4-chloro-1H-imidazol-5-yl)methyl]amino}-1H-imidazole-5-carboxamide (0.17 g, 0.37 mmol, obtained from Example 7(b)) was dissolved in ammonia (7 N in methanol, 3 mL) and the mixture was heated at 80° C. for 1 h. The mixture was concentrated and purified by preparative HPLC, obtaining the title compound (0.017 g, 14%) as a solid.

Workup

  1. concentrationThe mixture was concentrated
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-757add8cb20b4156b3fba721a0b8bfa6
Source dataset
uspto-grants-2011_09
Patent number
US08026244B2

Reaction notes

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