HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 912681Generated: November 1, 2026
Formamidine acetate → 3-[2-(1H-Benzimidazol-2-yl)ethyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one
https://huagongshe.com/reaction/912681
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamidine acetate | HCID 160693 | — |
| Reactant | 5,6-Diamino-1-[2-(1H-benzimidazol-2-yl)ethyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one | HCID 86631125 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-[2-(1H-Benzimidazol-2-yl)ethyl]-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one | HCID 24855502 | 12% |
Reaction Steps
To 5,6-diamino-1-[2-(1H-benzimidazol-2-yl)ethyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (0.29 g, 0.96 mmol, obtained from Example 12(c)) in DMSO (2 mL) was added formamidine acetate (0.15 g, 1.4 mmol) and the reaction was heated to 80° C. for 2 h. Purification of the crude product using preparative HPLC gave the title compound (0.035 g, 12% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08026244B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-f98d2907b1e2408eae10166c1ee07bfa |
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| Source note | uspto-grants-2011_09 |
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