Ammonia → HCID 178514164, compound

HRID 912682Notes

Reaction equation

HRID 912682 reaction equation
[N:1]1[NH:2][C:3](NC)=[CH:4][CH:5]=1.[C:8]([N:16]=[C:17]=[S:18])(=O)C1C=CC=CC=1.[NH3:19]>CO>[NH:1]1[CH:5]=[CH:4][C:3]([CH2:8][NH:16][C:17]([NH2:19])=[S:18])=[N:2]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 68284Benzoyl isothiocyanateHCID 22265630N-Methyl-1H-pyrazol-5-amine

Product 1

HCID 178514164HCID 178514164, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared in accordance with the general method described in Example 12(a) by using 2H-pyrazol-3-yl-methylamine (1.20 g, 12.4 mmol), benzoyl isothiocyanate (1.8 mL, 13.6 mmol) and ammonia in methanol (7N, 60 mL) with the exception that the crude product isolated by filtration (1.39 g, 72% yield) was used in the next step without further purification. MS (ESI) m/z 157 (M+1)

Workup

  1. customisolated by filtration (1.39 g, 72% yield)
  2. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-4e26e5919d2b42cf8a9cf0d7caae231b
Source dataset
uspto-grants-2011_09
Patent number
US08026244B2

Reaction notes

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