Sodium Dithionite → HCID 178508069, compound

HRID 912684Notes

Reaction equation

HRID 912684 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[CH:13]=[CH:12][NH:11][N:10]=2)[C:6](=[S:14])[NH:5][C:4](=[O:15])[CH:3]=1.[N:16]([O-])=O.[Na+].S(S([O-])=O)([O-])=O.[Na+].[Na+]>>[NH2:16][C:3]1[C:4](=[O:15])[NH:5][C:6](=[S:14])[N:7]([CH2:8][C:9]2[CH:13]=[CH:12][NH:11][N:10]=2)[C:2]=1[NH2:1]

Participants

4

Reactant 3

HCID 24489Sodium DithioniteHCID 23668193Sodium NitriteHCID 178507963HCID 178507963, compound

Product 1

HCID 178508069HCID 178508069, compoundYield 68.1%

Procedure

The title compound was prepared in accordance with the general method described in Example 12(c) by using 6-amino-1-(1H-pyrazol-3-ylmethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (0.87 g, 3.88 mmol, obtained from Example 13(b)), sodium nitrite (0.30 g, 4.27 mmol) and sodium dithionite (1.35 g, 7.77 mmol) which gave the title compound (0.63 g, 67% yield).

Workup

  1. customThe title compound was prepared in accordance with the general method

Sources & evidence

ORD record
ord-490f9d02b35b4ed19796aa6f7fcab6d6
Source dataset
uspto-grants-2011_09
Patent number
US08026244B2

Reaction notes

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