Sodium Dithionite → HCID 86631136, compound

HRID 912695Notes

Reaction equation

HRID 912695 reaction equation
[NH2:1][C:2]1[N:7]([CH2:8][C:9]2[C:13]([CH3:14])=[N:12][O:11][N:10]=2)[C:6](=[S:15])[NH:5][C:4](=[O:16])[CH:3]=1.[N:17]([O-])=O.[Na+].S(S([O-])=O)([O-])=O.[Na+].[Na+]>>[NH2:17][C:3]1[C:4](=[O:16])[NH:5][C:6](=[S:15])[N:7]([CH2:8][C:9]2[C:13]([CH3:14])=[N:12][O:11][N:10]=2)[C:2]=1[NH2:1]

Participants

4

Reactant 3

HCID 24489Sodium DithioniteHCID 23668193Sodium NitriteHCID 86631135HCID 86631135, compound

Product 1

HCID 86631136HCID 86631136, compoundYield 89.6%

Procedure

The title compound was prepared in accordance with the general method described in Example 12(c) by using 6-amino-1-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (0.44 g, 1.8 mmol, obtained from Example 16(b)), sodium nitrite (0.14 g, 2.0 mmol) and sodium dithionite (0.64 g, 3.7 mmol) which gave the title compound (0.41 g, 88% yield).

Workup

  1. customThe title compound was prepared in accordance with the general method

Sources & evidence

ORD record
ord-f348adb741b3476690b0169c720bd945
Source dataset
uspto-grants-2011_09
Patent number
US08026244B2

Reaction notes

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