HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-fluorobenzene → 1,1-Dimethylethyl 4-{2-[(4-bromophenyl)-oxy]ethyl}-1-piperidinecarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-fluorobenzene | HCID 9993 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine | HCID 854140 | — |
| Product | 1,1-Dimethylethyl 4-{2-[(4-bromophenyl)-oxy]ethyl}-1-piperidinecarboxylate | HCID 19034153 | 127% |
Reaction Steps
The procedure described in Example 4.1. is repeated. Starting from 1.93 g (8.4 mmol) of 1,1-dimethylethyl 4-(2-hydroxyethyl)-1-piperidine-carboxylate and 5.88 g (33.6 mmol) of 1-bromo-4-fluorobenzene gives 4.1 g of crude product in oil form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026258B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-8992b5a8046c4ffbbb2b6f09d4811536 |
| Source note | uspto-grants-2011_09 |