Diisopropylethylamine → HCID 11582407, compound

HRID 912797Notes

Reaction equation

HRID 912797 reaction equation
Cl.Cl.Cl.[F:4][C:5]([F:19])([F:18])[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][C:11]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.Cl[C:21]1[NH:25][C:24]2[CH:26]=[C:27]([C:30]([F:33])([F:32])[F:31])[CH:28]=[CH:29][C:23]=2[N:22]=1.C(N(CC)C(C)C)(C)C>>[F:33][C:30]([F:31])([F:32])[C:27]1[CH:28]=[CH:29][C:23]2[N:22]=[C:21]([N:15]3[CH2:16][CH2:17][N:12]([C:11]4[CH:10]=[CH:9][N:8]=[CH:7][C:6]=4[C:5]([F:4])([F:18])[F:19])[CH2:13][CH2:14]3)[NH:25][C:24]=2[CH:26]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 3379052-chloro-6-(trifluoromethyl)-1H-benzimidazoleHCID 86593827HCID 86593827, compound

Product 1

HCID 11582407HCID 11582407, compound

Procedure

The piperazine from step (b) above (0.55 g, 1.81 mmol), 2-chloro-6-trifluoromethyl-1H-benzoimidazole (0.4 g, 1.81 mmol, Example 1c) and N,N-diisopropylethylamine (0.63 mL, 3.62 mmol, Aldrich) reacted under the conditions of Example 3c to give the title compound as a light-yellow solid. M.p. 220-224° C. MS (ESI, pos. ion) m/z: 416 (M+1).

Sources & evidence

ORD record
ord-a4d1a7011bfe4894aa3be8ac029bc631
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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