HRID912824

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Fc1cc(-c2cc(C(F)(F)F)cc3[nH]c(Cl)nc23)cc(F)c1F

HCID11638867

未命名化合物

HCID67401356

未命名化合物

PRODUCTS

生成物

结构：CNS(=O)(=O)c1cccnc1N1CCN(c2nc3cc(C(F)(F)F)cc(-c4cc(F)c(F)c(F)c4)c3[nH]2)CC1

HCID178486270

未命名化合物

PROCEDURE

实验过程

The piperazine from step (a) above (128 mg, 0.5 mmol) reacted with 2-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole (140 mg, 0.4 mmol, Example 51b) under the conditions of Example 3c to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 571 (M+1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b1b2e67a5f2f42ad998211a253cb8bf9
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08026241B2
来源说明: uspto-grants-2011_09

反应 SMILES

[CH3:1][NH:2][S:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)(=[O:5])=[O:4].Cl[C:19]1[NH:23][C:22]2[CH:24]=[C:25]([C:37]([F:40])([F:39])[F:38])[CH:26]=[C:27]([C:28]3[CH:33]=[C:32]([F:34])[C:31]([F:35])=[C:30]([F:36])[CH:29]=3)[C:21]=2[N:20]=1>>[CH3:1][NH:2][S:3]([C:6]1[C:7]([N:12]2[CH2:17][CH2:16][N:15]([C:19]3[NH:20][C:21]4[C:27]([C:28]5[CH:29]=[C:30]([F:36])[C:31]([F:35])=[C:32]([F:34])[CH:33]=5)=[CH:26][C:25]([C:37]([F:40])([F:38])[F:39])=[CH:24][C:22]=4[N:23]=3)[CH2:14][CH2:13]2)=[N:8][CH:9]=[CH:10][CH:11]=1)(=[O:5])=[O:4]