{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanol → HCID 178461541, compound

HRID 912835Notes

Reaction equation

HRID 912835 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:15][OH:16])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][C@H:10]([CH3:14])[CH2:9]1.Cl[C:18]1[NH:22][C:21]2[CH:23]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:25]=[C:26]([I:27])[C:20]=2[N:19]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:15][OH:16])[CH:5]=[N:6][C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([C:18]2[NH:19][C:20]3[C:26]([I:27])=[CH:25][C:24]([C:28]([F:31])([F:29])[F:30])=[CH:23][C:21]=3[N:22]=2)[C@H:10]([CH3:14])[CH2:9]1

Participants

3

Reactant 2

HCID 11550484{5-Chloro-6-[(3R)-3-methylpiperazin-1-yl]pyridin-3-yl}methanolHCID 674014061H-Benzimidazole, 2-chloro-7-iodo-5-(trifluoromethyl)-

Product 1

HCID 178461541HCID 178461541, compound

Procedure

The piperazine from step (a) above (73 mg, 0.3 mmol) reacted with 2-chloro-4-iodo-6-(trifluoromethyl)-1H-benzoimidazole (69 mg, 0.2 mmol, Example 61c) under the conditions of Example 3c to give the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 552 (M+1).

Sources & evidence

ORD record
ord-30da44ed59eb4175b6d764cab7274123
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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