2-Methylpiperazine, (S)- → HCID 178461509, compound

HRID 912844Notes

Reaction equation

HRID 912844 reaction equation
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:20]([F:23])([F:22])[F:21])[CH:9]=[C:10]([C:11]3[CH:16]=[C:15]([F:17])[C:14]([F:18])=[C:13]([F:19])[CH:12]=3)[C:4]=2[N:3]=1.[CH3:24][C@H:25]1[CH2:30][NH:29][CH2:28][CH2:27][NH:26]1>>[CH3:24][C@@H:25]1[NH:26][CH2:27][CH2:28][N:29]([C:2]2[NH:3][C:4]3[C:10]([C:11]4[CH:16]=[C:15]([F:17])[C:14]([F:18])=[C:13]([F:19])[CH:12]=4)=[CH:9][C:8]([C:20]([F:23])([F:22])[F:21])=[CH:7][C:5]=3[N:6]=2)[CH2:30]1

Participants

3

Reactant 2

HCID 27342192-Methylpiperazine, (S)-HCID 116388672-chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole

Product 1

HCID 178461509HCID 178461509, compound

Procedure

2-Chloro-6-(trifluoromethyl)-4-(3,4,5-trifluorophenyl)-1H-benzoimidazole (350 mg, 1 mmol, Example 51b) reacted with (S)-(+)-2-methylpiperazine (150 mg. 1.5 mmol, Aldrich) under the conditions of Example 3c to give the title compound as a light-brown solid. MS (ESI, pos. ion) m/z: 415 (M+1).

Sources & evidence

ORD record
ord-4d285dc1591f4c0e9bc22b59c8f4d6e2
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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