3-Bromo-2-chloropyridine → HCID 178461511, compound

HRID 912845Notes

Reaction equation

HRID 912845 reaction equation
[CH3:1][C@@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]2[NH:12][C:11]3[C:13]([C:21]4[CH:26]=[C:25]([F:27])[C:24]([F:28])=[C:23]([F:29])[CH:22]=4)=[CH:14][C:15]([C:17]([F:20])([F:19])[F:18])=[CH:16][C:10]=3[N:9]=2)[CH2:3]1.[Br:30][C:31]1[C:32](Cl)=[N:33][CH:34]=[CH:35][CH:36]=1>>[Br:30][C:31]1[C:32]([N:7]2[CH2:6][CH2:5][N:4]([C:8]3[NH:12][C:11]4[C:13]([C:21]5[CH:26]=[C:25]([F:27])[C:24]([F:28])=[C:23]([F:29])[CH:22]=5)=[CH:14][C:15]([C:17]([F:18])([F:19])[F:20])=[CH:16][C:10]=4[N:9]=3)[CH2:3][C@@H:2]2[CH3:1])=[N:33][CH:34]=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 6933243-Bromo-2-chloropyridineHCID 178461509HCID 178461509, compound

Product 1

HCID 178461511HCID 178461511, compound

Procedure

The piperazine from step (a) above (41 mg, 0.1 mmol) reacted with 3-bromo-2-chloropyridine (19 mg, 0.1 mmol, Aldrich) under the conditions of Example 48b to give the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 570 (M+1).

Sources & evidence

ORD record
ord-9a52e8fae2de457c847376810251b05a
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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