4-Aminomethylphenylboronic acid hydrochloride → HCID 178509570, compound

HRID 912848Notes

Reaction equation

HRID 912848 reaction equation
Br[C:2]1[C:10]2[N:9]=[C:8]([N:11]3[CH2:16][CH2:15][N:14]([C:17]4[C:22]([C:23]([F:26])([F:25])[F:24])=[CH:21][CH:20]=[CH:19][N:18]=4)[CH2:13][CH2:12]3)[NH:7][C:6]=2[CH:5]=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.Cl.[NH2:32][CH2:33][C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1>>[F:30][C:27]([F:28])([F:29])[C:4]1[CH:3]=[C:2]([C:37]2[CH:38]=[CH:39][C:34]([CH2:33][NH2:32])=[CH:35][CH:36]=2)[C:10]2[NH:9][C:8]([N:11]3[CH2:12][CH2:13][N:14]([C:17]4[C:22]([C:23]([F:24])([F:25])[F:26])=[CH:21][CH:20]=[CH:19][N:18]=4)[CH2:15][CH2:16]3)=[N:7][C:6]=2[CH:5]=1

Participants

3

Reactant 2

HCID 27343114-Aminomethylphenylboronic acid hydrochlorideHCID 116704454-Bromo-6-trifluoromethyl-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole

Product 1

HCID 178509570HCID 178509570, compound

Procedure

The title compound was prepared from 4-bromo-6-trifluoromethyl-2-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-1H-benzoimidazole (Example 7) and 4-aminomethylphenylboronic acid hydrochloride (Acros) under the conditions of Example 51a and isolated as a white amorphous solid. MS (ESI, pos. ion) m/z: 521 (M+1).

Workup

  1. customisolated as a white amorphous solid

Sources & evidence

ORD record
ord-b1607349cff4488d81a1c107dd308bd2
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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