tert-Butyl piperazine-1-carboxylate → 4-Isoquinolin-7-yl-piperazine-1-carboxylic acid tert-butyl ester

HRID 912906Notes

Reaction equation

HRID 912906 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8](OS(C(F)(F)F)(=O)=O)[CH:9]=2)[CH:4]=[CH:3][N:2]=1.[C:19]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20]>>[C:22]([O:21][C:19]([N:26]1[CH2:31][CH2:30][N:29]([C:8]2[CH:9]=[C:10]3[C:5]([CH:4]=[CH:3][N:2]=[CH:1]3)=[CH:6][CH:7]=2)[CH2:28][CH2:27]1)=[O:20])([CH3:25])([CH3:23])[CH3:24]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 15171928Isoquinolin-7-yl trifluoromethanesulfonate

Product 1

HCID 674009894-Isoquinolin-7-yl-piperazine-1-carboxylic acid tert-butyl ester

Procedure

The product from step (a) above (300 mg, 1.1 mmol) and 1-BOC-piperazine (307 mg, 1.6 mmol, Aldrich) was reacted under the conditions of Example 132b to give the title compound as yellow amorphous solid, which was used for the next step. MS (ESI, pos. ion) m/z: 314 (M+1).

Sources & evidence

ORD record
ord-b5761fb5bdce4743b73387cdeb598e04
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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