HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl piperazine-1-carboxylate → 4-Isoquinolin-7-yl-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | Isoquinolin-7-yl trifluoromethanesulfonate | HCID 15171928 | — |
| Product | 4-Isoquinolin-7-yl-piperazine-1-carboxylic acid tert-butyl ester | HCID 67400989 | — |
Reaction Steps
The product from step (a) above (300 mg, 1.1 mmol) and 1-BOC-piperazine (307 mg, 1.6 mmol, Aldrich) was reacted under the conditions of Example 132b to give the title compound as yellow amorphous solid, which was used for the next step. MS (ESI, pos. ion) m/z: 314 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-b5761fb5bdce4743b73387cdeb598e04 |
| Source note | uspto-grants-2011_09 |