2-chloro-6-(trifluoromethyl)-1H-benzimidazole → HCID 178461518, compound

HRID 912920Notes

Reaction equation

HRID 912920 reaction equation
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[CH:9]=[CH:10][C:4]=2[N:3]=1.[CH3:15][C@H:16]1[NH:21][CH2:20][CH2:19][N:18]([C:22]2[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:17]1>O1CCOCC1>[CH3:15][C@@H:16]1[CH2:17][N:18]([C:22]2[C:27]([C:28]([F:31])([F:29])[F:30])=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:19][CH2:20][N:21]1[C:2]1[NH:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:5]=2[N:6]=1

Participants

4

Reactant 2

HCID 3379052-chloro-6-(trifluoromethyl)-1H-benzimidazoleHCID 11528875(R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazine

Product 1

HCID 178461518HCID 178461518, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 2-chloro-6-trifluoromethyl-1H-benzoimidazole (176 mg, 0.8 mmol, Example 1c) and (3R)-3-methyl-1-(3-trifluoromethyl-pyridin-2-yl)-piperazine (245 mg, 1.0 mmol, Example 79a) in dioxane (2 mL) reacted under the conditions of Example 3c to give the title compound. MS (ESI, pos. ion) m/z: 430 (M+1).

Workup

  1. customreacted under the conditions of Example 3c

Sources & evidence

ORD record
ord-89e04fc0ae824557b31b4bd6d34c7663
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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