HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-6-(trifluoromethyl)-1H-benzimidazole → HCID 178461518, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-6-(trifluoromethyl)-1H-benzimidazole | HCID 337905 | — |
| Reactant | (R)-3-Methyl-1-(3-(trifluoromethyl)pyridin-2-yl)piperazine | HCID 11528875 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 178461518 | HCID 178461518 | — |
Reaction Steps
A mixture of 2-chloro-6-trifluoromethyl-1H-benzoimidazole (176 mg, 0.8 mmol, Example 1c) and (3R)-3-methyl-1-(3-trifluoromethyl-pyridin-2-yl)-piperazine (245 mg, 1.0 mmol, Example 79a) in dioxane (2 mL) reacted under the conditions of Example 3c to give the title compound. MS (ESI, pos. ion) m/z: 430 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-89e04fc0ae824557b31b4bd6d34c7663 |
| Source note | uspto-grants-2011_09 |