2-Methylpiperazine, (R)- → 2-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl]-propan-2-ol

HRID 912935Notes

Reaction equation

HRID 912935 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([OH:12])([CH3:11])[CH3:10])[CH:5]=[N:6][C:7]=1Cl.[CH3:13][C@@H:14]1[CH2:19][NH:18][CH2:17][CH2:16][NH:15]1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([OH:12])([CH3:11])[CH3:10])[CH:5]=[N:6][C:7]=1[N:18]1[CH2:17][CH2:16][NH:15][C@H:14]([CH3:13])[CH2:19]1

Participants

3

Reactant 2

HCID 73304342-Methylpiperazine, (R)-HCID 772303002-(5,6-Dichloropyridin-3-yl)propan-2-ol

Product 1

HCID 674004392-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl]-propan-2-ol

Procedure

A mixture of 2-(5,6-dichloro-pyridin-3-yl)-propan-2-ol from step (b) above (140 mg, 0.68 mmol) and (R)-(−)-2-methyl-piperazine (75 mg, 0.75 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound. MS (ESI, pos. ion) m/z: 270 (M+1).

Workup

  1. customreacted under the conditions of Example 3a

Sources & evidence

ORD record
ord-43527ccf8a0f4dc79dc37727f1ba60ee
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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