HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpiperazine, (R)- → 2-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl]-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpiperazine, (R)- | HCID 7330434 | — |
| Reactant | 2-(5,6-Dichloropyridin-3-yl)propan-2-ol | HCID 77230300 | — |
| Product | 2-[5-Chloro-6-[(3R)-3-methyl-piperazin-1-yl]-pyridin-3-yl]-propan-2-ol | HCID 67400439 | — |
Reaction Steps
A mixture of 2-(5,6-dichloro-pyridin-3-yl)-propan-2-ol from step (b) above (140 mg, 0.68 mmol) and (R)-(−)-2-methyl-piperazine (75 mg, 0.75 mmol, Aldrich) reacted under the conditions of Example 3a to give the title compound. MS (ESI, pos. ion) m/z: 270 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08026241B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-43527ccf8a0f4dc79dc37727f1ba60ee |
| Source note | uspto-grants-2011_09 |