4-Chlorobenzoic Acid → HCID 178461547, compound

HRID 912956Notes

Reaction equation

HRID 912956 reaction equation
[NH2:1][C:2]1[C:7]2[NH:8][C:9]([N:11]3[CH2:16][CH2:15][N:14]([C:17]4[N:22]=[CH:21][C:20]([CH2:23][OH:24])=[CH:19][C:18]=4[Cl:25])[CH2:13][C@H:12]3[CH3:26])=[N:10][C:6]=2[CH:5]=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=1.[Cl:31][C:32]1[CH:40]=[CH:39][C:35]([C:36](O)=[O:37])=[CH:34][CH:33]=1>>[Cl:31][C:32]1[CH:40]=[CH:39][C:35]([C:36]([NH:1][C:2]2[C:7]3[NH:8][C:9]([N:11]4[CH2:16][CH2:15][N:14]([C:17]5[C:18]([Cl:25])=[CH:19][C:20]([CH2:23][OH:24])=[CH:21][N:22]=5)[CH2:13][C@H:12]4[CH3:26])=[N:10][C:6]=3[CH:5]=[C:4]([C:27]([F:30])([F:29])[F:28])[CH:3]=2)=[O:37])=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 63184-Chlorobenzoic AcidHCID 178461542HCID 178461542, compound

Product 1

HCID 178461547HCID 178461547, compound

Procedure

{6-[(3R)-4-(7-Amino-5-trifluoromethyl-1H-benzoimidazol-2-yl)-3-methyl-piperazin-1-yl]-5-chloro-pyridin-3-yl}-methanol (221 mg, 0.5 mmol, Example 175b) and 4-chloro-benzoic acid (86 mg, 0.55 mmol, Aldrich) reacted under the conditions of Example 65 to give the title compound as a white solid. MS (ESI, pos. ion) m/e: 579 (M+1).

Sources & evidence

ORD record
ord-cde1e1d4723241fc9b747eecb72cfe4f
Source dataset
uspto-grants-2011_09
Patent number
US08026241B2

Reaction notes

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