Benzophenone → (2-Chlorophenyl)diphenylmethanol

HRID 913043Notes

Reaction equation

HRID 913043 reaction equation
[Mg].Br[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[Cl:9].[C:10]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[Cl:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:10]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[OH:17]

Participants

4

Reactant 3

HCID 3102BenzophenoneHCID 127541-Bromo-2-chlorobenzeneHCID 5462224Magnesium

Product 1

HCID 298659(2-Chlorophenyl)diphenylmethanolYield 64%

Procedure

Following the procedure outlined in Example 1, 1.3 g (52 mmol) of magnesium turnings, 10.0 g (52 mmol) of 1-bromo-2-chlorobenzene and 9.4 g (52 mmol) benzophenone gave 9.81 g (64%) of (2-Chlorophenyl) diphenyl methanol (Compound T3), mp: 91° C.

Sources & evidence

ORD record
ord-3ba773148c994e52aa0095ae575d3cf5
Source dataset
uspto-grants-2011_09
Patent number
US08026263B2

Reaction notes

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