Hydrochloric Acid → HCID 67399839, compound

HRID 913084Notes

Reaction equation

HRID 913084 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:23])[NH2:22])=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[ClH:24].[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH2:22])=[O:23])=[CH:17][N:16]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67218281HCID 67218281, compound

Product 1

HCID 67399839HCID 67399839, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(5-carbamoyl-pyridin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.63 g, 1.97 mmol) in 4 M HCl in dioxane (20 mL) was stirred at rt for 1 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 221.4 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-c48b66f8c8214146b0f6df49e27f63c8
Source dataset
uspto-grants-2011_09
Patent number
US08026255B2

Reaction notes

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