Hydrochloric Acid → HCID 178478552, compound

HRID 913086Notes

Reaction equation

HRID 913086 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[NH:25][N:24]=[N:23][N:22]=3)=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[ClH:26].[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[NH:25][N:24]=[N:23][N:22]=3)=[CH:17][N:16]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178452071HCID 178452071, compound

Product 1

HCID 178478552HCID 178478552, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-[5-(1H-tetrazol-5-yl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (0.80 g, 2.32 mmol) in 4 M HCl in dioxane (60 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 246.4 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-d048570872b74556a66333cb855f4c75
Source dataset
uspto-grants-2011_09
Patent number
US08026255B2

Reaction notes

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