Hydrochloric Acid → (4-Methyl-quinolin-2-yl)-piperidin-4-yl-amine dihydrochloride

HRID 913094Notes

Reaction equation

HRID 913094 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:24]=[C:23]([CH3:25])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[ClH:26].[CH3:25][C:23]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[N:16]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 674000874-(4-Methyl-quinolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 67400534(4-Methyl-quinolin-2-yl)-piperidin-4-yl-amine dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(4-methyl-quinolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.54 g, 1.58 mmol) in 4 M HCl in dioxane (50 mL) was stirred at rt for 1 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 242.4 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-86f5a1bd7da64430af772439c9338a4b
Source dataset
uspto-grants-2011_09
Patent number
US08026255B2

Reaction notes

Loading…