Hydrochloric Acid → HCID 67401266, compound

HRID 913100Notes

Reaction equation

HRID 913100 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[ClH:25].[C:15]1([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][N:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67400646HCID 67400646, compound

Product 1

HCID 67401266HCID 67401266, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(isoquinolin-1-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.83 g, 2.54 mmol) in 4 M HCl in dioxane (100 mL) was stirred at rt for 1 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 228.6 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-20ed0653a89a4724933ef4fe5c34331d
Source dataset
uspto-grants-2011_09
Patent number
US08026255B2

Reaction notes

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