Hydrochloric Acid → HCID 67398466, compound

HRID 913129Notes

Reaction equation

HRID 913129 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[C:19]([C:21]#[N:22])[CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[ClH:23].[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]2[CH:20]=[C:19]([CH:18]=[CH:17][N:16]=2)[C:21]#[N:22])[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67398920HCID 67398920, compound

Product 1

HCID 67398466HCID 67398466, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(4-cyano-pyridin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.30 g, 1.00 mmol) in 4 M HCl in dioxane (15 mL) was stirred at rt for 1 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 203.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-387ea7bafffd41ef89ef8394ad003b06
Source dataset
uspto-grants-2011_09
Patent number
US08026255B2

Reaction notes

Loading…