Hydrochloric Acid → HCID 59383092, compound

HRID 913150Notes

Reaction equation

HRID 913150 reaction equation
ClC1C=CC(CN2CCC(NC3C=CC(C#N)=CC=3)CC2)=CC=1OCC.[CH3:27][O:28][C:29](=[O:51])[C:30]1[CH:35]=[C:34]([Cl:36])[N:33]=[C:32]([NH:37][CH:38]2[CH2:43][CH2:42][N:41](C(OC(C)(C)C)=O)[CH2:40][CH2:39]2)[CH:31]=1.Cl>O1CCOCC1.C(O)C>[CH3:27][O:28][C:29](=[O:51])[C:30]1[CH:31]=[C:32]([NH:37][CH:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)[N:33]=[C:34]([Cl:36])[CH:35]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 24854967HCID 24854967, compoundHCID 86618561HCID 86618561, compound

Product 1

HCID 59383092HCID 59383092, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared in analogy to the synthesis of (5-methanesulfonyl-pyridin-2-yl)-piperidin-4-yl-amine (intermediate B16/step 2) from 2-(1-tert-butoxycarbonyl-piperidin-4-ylamino)-6-chloro-isonicotinic acid methyl ester by cleavage of the BOC group with 4 M HCl in dioxane and ethanol at rt. MS (ISP): 270.1 [M+H]+.

Sources & evidence

ORD record
ord-5bbe7fa7805c4744a8569ed687388b3e
Source dataset
uspto-grants-2011_09
Patent number
US08026255B2

Reaction notes

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