Hydrochloric Acid → HCID 59383098, compound

HRID 913158Notes

Reaction equation

HRID 913158 reaction equation
ClC1C=CC(CN2CCC(NC3C=CC(C#N)=CC=3)CC2)=CC=1OCC.C(OC([N:34]1[CH2:39][CH2:38][CH:37]([N:40](C(OC(C)(C)C)=O)[C:41]2[CH:46]=[CH:45][C:44]([O:47][S:48]([CH3:51])(=[O:50])=[O:49])=[CH:43][N:42]=2)[CH2:36][CH2:35]1)=O)(C)(C)C.Cl>O1CCOCC1.C(O)C>[NH:34]1[CH2:39][CH2:38][CH:37]([NH:40][C:41]2[N:42]=[CH:43][C:44]([O:47][S:48]([CH3:51])(=[O:49])=[O:50])=[CH:45][CH:46]=2)[CH2:36][CH2:35]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 24854967HCID 24854967, compoundHCID 86618562HCID 86618562, compound

Product 1

HCID 59383098HCID 59383098, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

The title compound was prepared in analogy to the procedure described for (5-methanesulfonyl-pyridin-2-yl)-piperidin-4-yl-amine (intermediate B16/step 2) from 4-[tert-butoxycarbonyl-(5-methanesulfonyloxy-pyridin-2-yl)-amino]-piperidine-1-carboxylic acid tert-butyl ester by cleavage of the BOC group with 4 M HCl in dioxane and ethanol at 70° C. MS (ISP): 272.1 [M+H]+.

Sources & evidence

ORD record
ord-0eda279c0e13451e84691d1e62de2602
Source dataset
uspto-grants-2011_09
Patent number
US08026255B2

Reaction notes

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