反应详情

A mixture of 1 1,4-bis[(phenylmethyl)oxy]-2,3-naphthalenedicarboxylic acid (5.0 g, 11.68 mmol), ethyl (4-amino-3-chlorophenyl)acetate (4.74 g, 22.2 mmol) and DMAP (0.427 g, 3.59 mmol) were heated to 120° C. in acetic acid (20 ml) for 18 hours. Water was added and the mixture and resulting brown solid collected by filtration and washed with water. This was triturated with ether to give a cream solid which was collected by filtration and dried in the vacuum oven (5.34 g, 8.83 mmol). LC/MS: Rt=4.15, [MH]+ 606.

1. customthe mixture and resulting brown solid
2. filtrationcollected by filtration
3. washwashed with water
4. customThis was triturated with ether
5. customto give a cream solid which
6. filtrationwas collected by filtration
7. customdried in the vacuum oven (5.34 g, 8.83 mmol)