反应详情

Ethyl (3-chloro-4-{4-(ethyloxy)-1,3-dioxo-9-[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetate (0.060 g, 0.11 mmol) was heated to 100° C. in a 1:1 mixture of acetic acid:HCl (2N) (6 ml) for 1.25 hours. On addition of water, the resulting white solid was collected by filtration and washed with water (0.047 g, 0.09 mmol). LC/MS: Rt=3.44, [MH]+ 508.

1. filtrationthe resulting white solid was collected by filtration