Acetyl chloride → DIMETHYL ACETYLPHOSPHONATE

HRID 913206Notes

Reaction equation

[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][O:6][P:7]([O:10]C)[O:8][CH3:9]>>[C:1]([P:7](=[O:10])([O:8][CH3:9])[O:6][CH3:5])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 8472Trimethyl phosphite

Product 1

HCID 2785315DIMETHYL ACETYLPHOSPHONATE

Conditions

Temperature: 80 °C

Procedure

Acetyl chloride (7.85 ml, 110 mmol) was cooled to 0° C. and stirred. Trimethylphosphite (11.8 ml, 100 mmol) was added drop-wise over one hour while the cooling was maintained. The mixture was then heated to 80° C. for 5 minute to remove un-reacted acetyl chloride (the flow of argon accelerates the process). The crude product was used in the next step without additional purification (theoretical yield is 15.2 g).

Workup

temperaturewas maintained
customto remove
customun-reacted acetyl chloride (the flow of argon
customThe crude product was used in the next step without additional purification (theoretical yield is 15.2 g)

Sources & evidence

ORD record: ord-8a98fc38509e461d81c3130a305f5db4
Source dataset: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08026278B2

Reaction notes

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