Cyclopentylamine → 4-(2-chloro-4-pyridinyl)-N-cyclopentyl-2-pyrimidinamine

HRID 913291Notes

Reaction equation

HRID 913291 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[C:12]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([Cl:20])[CH:15]=2)[CH:11]=[CH:10][N:9]=1>>[Cl:20][C:16]1[CH:15]=[C:14]([C:12]2[CH:11]=[CH:10][N:9]=[C:8]([NH:6][CH:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)[N:13]=2)[CH:19]=[CH:18][N:17]=1

Participants

3

Reactant 2

HCID 2906CyclopentylamineHCID 581026912-Chloro-4-(2-chloropyridin-4-yl)pyrimidine

Product 1

HCID 866467774-(2-chloro-4-pyridinyl)-N-cyclopentyl-2-pyrimidinamine

Procedure

Cyclopentylamine (3 mL) was combined with 2-chloro-4-(2-chloro-4-pyridinyl)pyrimidine (i.e., the product of Example 6, Step A) (300 mg, 1.3 mmol) and stirred at 55° C. for 2 hours. The resulting suspension was filtered, and the collected solid was oven dried at 50° C. in vacuo to give 340 mg of the title compound as a brown solid.

Workup

  1. filtrationThe resulting suspension was filtered
  2. customdried at 50° C. in vacuo

Sources & evidence

ORD record
ord-7210efd6997f4e2db5ea580956d2e3d8
Source dataset
uspto-grants-2011_09
Patent number
US08026359B2

Reaction notes

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